Job rhiya

https://www.sarkariresullts.comeat up dead ones and clean them. Now, this biological mechanism can be used to treat severe ophthalmological disputes like dry eyes, keratoconus and age-related degeneration, research by a Bengaluru ophthalmologist has found. Dr Rohit Shetty has come up with a therapeutic method based on the self-defence mechanism of cells -- where living cells eat up the dead ones to repair severed eye cells -- to cure eye-related complications.

Dr Shetty’s work is based on a study by Japanese scientist Yoshinori Ohsumi, who used baker’s yeast to identify genes essential for autophagy and won the Nobel Prize in physiology or medicine last year for the same.

“We have been working on questions and mysteries of what really causes a disease. However, most of us are busy treating the conditions rather than finding the reasons behind them, which would essentially help us treat that condition in a holistic way. Our approach was to find out the causes, study them and then create a novel medication that would cure the ailment at an early stage so that treatment is effective, safe, preventive and cheap,” said Dr Shetty.

Dr Shetty’s research was spurred by his curiosity about autophagy. “Although the concept has been used to treat cancer, Alzheimer’s and Parkinson’s abroad, its benefits weren’t being explored in ophthalmology. Now that it has been found, people should know that even Indians can contribute towards life-saving therapies,” he added.

The study, for the first time, indicated the role of autophagy in causing dry eyes, considered a modern epidemic among the young, and keratoconus, a disease that weakens the cornea, even requiring a transplant at times.

“Once we figured the role of autophagy in these ailments, we wanted to work on altered autophagy (correction and restarting of the biological mechanism). We came to know of a new mechanism on how the disease can occur due to oxidative stress and how altered autophagy could prevent its revival. Based on this, we came up with India’s own therapeutic option to control dry eye and keratoconus,” said Dr Shetty.

How it works

It’s known that autophagy abates with age, contributing to eye ailments like muscular degeneration, dry eyes and glaucoma. As such, if the autophagy procedure is corrected or re-started (altered autophagy), the aliment can be treated.

Meditation, fasting can help

Oxidative stress causes autophagy to abate, triggering ailments as dead cells keep on accumulating instead of being cleared out by the living ones. This is where meditation and yoga play a major role in initiating altered autophagy. They reduce oxidative stress, improve cell survival, leading to better housekeeping and cleaning of dead cells. Fasting one day a week also helps reboot this mechanism and cure a disease.

Aim to prevent needless blindness

Now, we are working to use this research to resolve retina-related issues and address the wide incidence of glaucoma, a condition of increased pressure within the eyeball causing gradual loss of sight. We hope to use the same mechanism of autophagy and prevent needless blindness Dr Rohit Shetty | Narayana Nethralaya A case in point Reya (name changed), 26, who worked for an animation company, was suffering from severe pain in her eyes. She was diagnosed with keratoconus that affected her corneas, making them weak. The pain not only affected her quality of life, but also forced her to leave her job. Riya was treated with the therapeutic tool based on autophagy mechanism of living cells. She is doing fine now and is back to work.

02

Changing generations

How do women of different generations but the same family feel about love, marriage and work? We map changing mindsets, behaviour and attitude of women across three generations. Suchitra Sen, 78, grandmotherLove & Marriage: The emotions that drove Suchitra Sen emotionally were dignity and grace. ���My mother understood the sanctity of marriage, love and relationships. Marriages in her time had to last a lifetime. There was great stress on togetherness,��� says Suchitra's daughter, Moon Moon Sen. Suchitra married Dibanath Sen, son of a wealthy Bengali industrialist, in 1947 and had one child, Moon Moon Sen.

Women & Acting: During Suchitra's acting days, she made sure people respected her for her art. Those days, there were few women in acting. Of course, there was yellow journalism. ���I was kept away from the harsh world of acting and media. My mother belonged to a very good family and acting in those days was still taboo. My mother kept me away from all the gossip. She did everything with great dignity. Acting was a 9 to 5 jobs, nothing was so elaborate like it is now,'' adds Sen.

Moon Moon Sen, 51, motherLove & Marriage: ���Love in those days, wasn't like love today. It was more meaningful then. Men encouraged their wives to pursue their dreams. After I married Bharat Dev Varma, of the royal family of Tripura, he allowed me to pursue my dreams. I remember, my husband and kids would come and see me on the sets as I modelled and acted. There was a new bonding in relationships. From my mother's time to mine, I saw couples had to spend time away from each other, as they pursued different careers, so a husband got a green card and worked in US, while the wife brought up the kids here. In my daughter's generation, marriage isn't the end-all.���

Women & Acting: ���Well, I had just finished my masters in Comparative Literature, when I thought of trying some modelling. It was considered ���cheap��� to be a model in those days, you were looked down upon. Everyone said, ���What's wrong with Suchitra's daughter, she wants to be a model.��� Being a model was a big taboo those days. I had a very different and modern outlook. I was a rebel. I worked night and day. My husband and children have been a part of my working life. I pursued my work after marriage. Being married never bothered me. I took my little girls on the sets. Little did I know they had harboured ambitions of becoming actors. These days, everyone wants to be in a movie star. There's MTV, Channel V - there's great opportunity. From my mother's time to today, we've come a very long way. The girls have a right to try out everything, acting is like any other job.���

Riya Sen, 28, daughterLove and Marriage: ���I believe being a woman is not half as easy as being a man, but it is wonderful. It's about strength, vitality and power of producing. Love still is the most beautiful feeling that ever exists. It can never go out of fashion. It conquers all. It's eternal. While marraiges, I believe, are made in heaven. You have to be ready to devote yourself completely to your partner.''

Women & acting: ���Times have really changed now, from my grandmother's time. Acting is a very professional thing. You have to be perfect in every shot. Technically, we're much more ahead than we were. So, there needs to be a greater discipline and commitment. And the money you make is a result of the love affair with your work.

Sumitra Charat Ram, 95, grandmotherOn love: In the autumn of her life, Sumitra Charat Ram makes the rules. Like she did, 70 years ago, when she married industrialist Lala Charat Ram, ���We fell in love, he had come to stay in my parents��� house in Nainital. I was three years elder to him, in those days it was unheard of, men didn't marry older women.''

The first date: ���It wasn't a date, date. We walked around Nainital and enjoyed a cup of tea away from my relatives��� glares. It was innocent. Once, my husband boarded a train to Benaras to meet me, when I was studying there.���

Marriage: ���I was married to my husband for 68 years, we romanced for seven years before actually tying the knot. Love and marriage were pure.���

Life views: ���I was born into a well-known family of UP, brought up in a joint family. I didn't need to work. But I had an interest in art, so I opened Shriram Bharatiya Kala Kendra.''

Money: ���We have to be accountable for the money we spend. Money should instill discipline.���

Shobha Deepak Singh, 65, motherOn love: ���I had a love marriage. When I joined my father's company, my husband was my boss. We both worked for my father. We fell in love instantly. But I didn't tell my parents about him for a long while.���

The first date: ���We dated in Cafe Chinos at The Oberoi rooftop in those days. I wasn't the disco kinds, those days were fun.���

Marriage: ���My husband was clear I had to be Mrs Shobha Deepak Singh and not just industrialist Charat Ram���s daughter. My mother-in-law was a culinary expert in Delhi. I gave up my job and started learning cooking from her. They treated me as their daughter. I've been encouraged by my husband to work and be financially independent. So, I gave my all to Shriram Bharatiya Kala Kendra. I was always treated as a daughter and this is also the reason I prefer a nuclear family to a joint family. To quote Gibran, ���there should be spaces in togetherness���.

Money: ���As for money, though I have adequate, I find that it does not stay with me. I prefer to spend and indulge myself and am fond of art, fabrics; photography and jewellery.���

Pallavi, 40, daughterOn love: ���I'm very modern in my life views like my mother and grandmother. As they had a love marriage so did I. I had no problems in marrying the man I loved. I met my husband while studying MBA in England.���

The first date: ���Very chilled out and relaxed on the college campus.���Marriage: ���Right now, I'm helping my husband in his business. I've three children and am enjoying bring them up. I would love to have a `marriage' like my mother and grandmother.Money: ���I'm very careful with the way I deal with money. Because I want to give the best to my children.���Back to Women���s Day Special